Clonazolam is a benzodiazepine that was developed as a central nervous system depressant in the 1970s and has recently emerged as a drug of abuse. It potently antagonizes convulsions induced by thiosemicarbazide and pentobarbital (ED50s = 90 µg/kg for both agonists in mice). In vitro phase I metabolites of clonazolam, derived from human liver microsomes, have been described. This product is intended for forensic and research applications.
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