Regarding the potency of alpha-PHP in the brain, chemist Michael H. Baumann of the Designer Drug Research Unit (established by Baumann) of the National Institute on Drug Abuse stated:
“alpha-PHP might be even more potent than alpha-PVP”; this statement is based on laboratory tests of chemical reactivity.
α-Pyrrolidinohexiophenone (α-PHP, A-PHP, Aphp, alpha-PHP, α-Pyrrolidinohexanophenone, PV-7) is a synthetic stimulant drug of the cathinone class developed in the 1960s which has been reported as a novel designer drug
alpha-Pyrrolidinohexiophenone (also known as PV-7, alpha-PHP, A-PHP, and α-PHP) is a lesser-known novel stimulant substance of the cathinone class. It is structurally related to MDPV and is one of the successors to the designer drug cathinone analog α-PVP.
It is being used and marketed as a replacement for α-PVP (known on the street as flakka) a few years following its ban, where it has come to substitute α-PVP in many parts of the world.
While initially mass synthesized in Chinese industrial laboratories, a ban on α-PHP within China’s borders has forced production to nations worldwide.
It generally comes in the form of either a fine powder or crystallized shards that can produce powerful but short-lived euphoric stimulant effects comparable to those of vaporized Methamphetamine and cocaine.
Like its cathinone predecessors, it is has gained notoriety for its tendency to induce compulsive redosing and addictive behaviors as well the ability to produce delusional states and psychosis when abused.
Very little data exists about the pharmacological properties, metabolism, and toxicity of α-PHP.
It has recently become commonly marketed alongside research chemical stimulants like NEP and Hexen as a legal, grey-market alternative to α-PVP, and commercially distributed through online research chemical vendors.
It is highly advised to use harm reduction practices if using this substance.
Legality – α-Pyrrolidinohexiophenone
In the United States, α-PHP in the past has been assigned to Schedule I on a Temporary Placement basis, although the order has expired without renewal or permanent placement and is no longer Scheduled at the Federal level as of July 2021.
Despite this however, α-PHP may be considered an analogue of α-PVP, a Schedule I drug under the Controlled Substances Act.
As such, possession or the sale for human consumption or the use for illicit non-medical or industrial intents and purposes could be prosecuted as crimes under the Federal Analogue Act.
Sweden’s public health agency suggested to classify α-PHP as narcotic on June 1, 2015.
As of October 2015, α-PHP is a controlled substance in China.
As of October 29, 2021, α-PHP has been banned in the Netherlands under the 1971 Vienna Convention on Psychotropic Substances.
Chemistry – α-Pyrrolidinohexiophenone
α-PHP, or α-Pyrrolidinohexanophenone, is a compound of the substituted cathinone and substituted pyrrolidine chemical classes. Its structure is comprised of hexanal bound to a phenyl ring at the 1 position and the nitrogen of a pyrrolidine ring at the 2 position.
α-PHP is the longer chain homolog of α-PVP, possessing an additional carbon on the alkyl side chain.
Pharmacology – α-Pyrrolidinohexiophenone
The mechanism of action of α-PHP is unknown. Aside from a substantially shorter duration, it is believed to act similarly to the designer drugs pentedrone and α-PVP, which both act as a potent norepinephrine–dopamine reuptake inhibitors (NDRI).
Although no substantial research on the pharmacology of this compound has yet been conducted.
This means it may effectively boost the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft.
Subjective effects – α-Pyrrolidinohexiophenone
In comparison to its predecessor α-PVP, this compound has been reported as inducing slightly less anxiety, uncomfortable side effects, euphoria, and an easier comedown.
Disclaimer: The effects listed below cite the Subjective Effect Index (SEI), an open research literature based on anecdotal user reports and the personal analyses of PsychonautWiki contributors. As a result, they should be viewed with a healthy degree of skepticism.
It is also worth noting that these effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects. Likewise, adverse effects become increasingly likely with higher doses and may include addiction, severe injury, or death.
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